PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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National Center for Biotechnology InformationU. Familial breast-ovarian cancer locus on chromosome 17qq However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested.

Genetic epidemiology of breast cancer: Associated Data Supplementary Materials. Genetic epidemiology of breast cancer in Britain. Am J Hum Genet. Inheritance of proliferative breast disease in breast cancer kindreds.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Estimating the power of linkage analysis in hereditary breast cancer. Inheritance of human breast cancer: Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among vamilial families, suggesting that linkage is restricted to early-onset disease.

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Support Center Support Center. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Segregation and linkage analysis of nine Utah breast cancer pedigrees.

Linkage of early-onset familial breast cancer to chromosome 17q

A new statistical test for linkage heterogeneity. This article has been cited by other articles in PMC. Linkage of early-onset familial breast cancer to chromosome 17q This article has been corrected. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

Linkage of early-onset familial breast cancer to chromosome 17q21.

Open in a separate window. Closing in on a breast cancer gene on chromosome 17q. Genetic analysis of breast cancer in the cancer chormosome steroid hormone study. Author information Copyright and License information Disclaimer.

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Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Strategies for multilocus linkage analysis in humans. See Am J Hum Genet.

Please review our privacy policy. Abstract Lod scores for linkage dancer familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.

There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset.