PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 17q211 more frequently positive among families with disease diagnosed at younger ages than lonkage are among older-onset families, suggesting that linkage is restricted to early-onset disease. There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset.

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Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease. Genetic epidemiology of breast cancer in Britain.

The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Familial breast-ovarian cancer locus on chromosome 17qq Estimating the power of linkage analysis in hereditary breast cancer. Genetic analysis of breast cancer in the cancer and steroid hormone study.

Linkage of early-onset familial breast cancer to chromosome 17q

See Am J Hum Genet. Strategies for multilocus linkage analysis in humans. Segregation and linkage analysis of nine Utah fsmilial cancer pedigrees. Am J Hum Genet.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

This article has been corrected. National Center for Biotechnology InformationU. A new statistical test for linkage heterogeneity.

Genetic epidemiology of breast cancer: Author information Copyright and License information Disclaimer. Please review our privacy policy.

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Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

However, for late-onset cases, the relative probability of sporadic brewst than inherited disease is higher than previously suggested. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

Inheritance of proliferative breast disease in breast cancer kindreds. Inheritance of human breast cancer: Closing in on a breast cancer gene on chromosome 17q. This article has been cited by other articles in PMC.

Linkage of early-onset familial breast cancer to chromosome 17q